Table of contents
- Vitamin D Status and Potential Therapeutic Options in Critically Ill Patients: A Narrative Review of the Clinical Evidence
- VitaminDWiki - Sepsis is both prevented and treated by Vitamin D - many studies contains
- VitaminDWiki -
38 studies in both categories Trauma-Surgery and Loading Dose
Vitamin D Status and Potential Therapeutic Options in Critically Ill Patients: A Narrative Review of the Clinical Evidence
Diagnostics 2022, 12(11), 2719; https://doi.org/10.3390/diagnostics12112719
Cutuli, S.L.; Cascarano, L.; Tanzarella, E.S.; Lombardi, G.; Carelli, S.; Pintaudi, G.; Grieco, D.L.; De Pascale, G.; Antonelli, M.Vitamin D covers roles of paramount importance in the regulation of multiple physiological pathways of the organism. The metabolism of vitamin D involves kidney–liver crosstalk and requires an adequate function of these organs, where vitamin D is progressively turned into active forms. Vitamin D deficiency has been widely reported in patients living in the community, being prevalent among the most vulnerable subjects. It has been also documented in many critically ill patients upon admission to the intensive care unit. In this context, vitamin D deficiency may represent a risk factor for the development of life-threatening clinical conditions (e.g., infection and sepsis) and worse clinical outcomes. Several researchers have investigated the impact of vitamin D supplementation showing its feasibility, safety, and effectiveness, although conflicting results have put into question its real benefit in critically ill patients. The existing studies included heterogeneous critically ill populations and used slightly different protocols of vitamin D supplementation. For these reasons, pooling up the results is difficult and not conclusive.
In this narrative review, we described vitamin D physiology and the pathophysiology of vitamin D depletion with a specific focus on critically ill patients with- liver dysfunction,
- acute kidney injury,
- acute respiratory failure, and
- sepsis.
Download the PDF from VitaminDWiki
This study incorrectly assumes that 30 ng of Vitamin D is sufficient for the critical ill, but fails to say levels achieved
Vitamin D Treats 150 ng Multiple Sclerosis * 80 ng Cluster Headache *
Reduced office visits by 4X *70 ng Sleep * 60 ng Breast Cancer death reduced 60%
Preeclampsia RCT50 ng COVID-19
T1 Diabetes
Fertility
Psoriasis
Infections Review
Infection after surgery40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?30 ng Rickets * Evolution of experiments with patients, often also need co-factors
VitaminDWiki - Sepsis is both prevented and treated by Vitamin D - many studies contains
- Sepsis is more likely in those with poor immune systems
Infants, the elderly, the sick, and those with low vitamin D - Severe sepsis has been associated with low Vitamin D and poor Vitamin D receptor in many studies
- Loading doses of Vitamin D bypass any poor Vitamin D Receptors
- Vitamin D loading doses have been proven to treat sepsis (RCTs: 2015, 2020, 2021)
Reduced: ICU stay by 8 days, Hospital stay by 7 days, and readmission rate reduced to 0%
Note: The fastest way (2 hours) to have a sublingual loading dose of Vitamin D nano-emulsion - Sepsis is fought by Vitamin D in 9 ways – Feb 2023
VitaminDWiki -
38 studies in both categories Trauma-Surgery and Loading Dose This list is automatically updated
- Surgery complications cut in half by 300,000 IU of vitamin D 2 weeks before (hip and knee) – RCT May 2024
- Some ICU patients got 540,000 IU of Vitamin D: good responders lived longer than controls or poor responders – RCT June 2024
- Large dose Vitamin D before surgery was found to help by 35 studies
- Vitamin D is needed before most surgeries – many studies and RCTs
- Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT April 2022
- ICU mortality reduced by non-oral vitamin D – meta-analysis May 2021
- Taking Vitamin D just before and after surgery helps (open-heart in this case) – RCT Feb 2021
- Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT Jan 2021
- Fewer days in hospital if 300,000 IU of vitamin D before brain surgery - RCT Feb 2021
- ICU Vitamin D injection (300,000 IU) helped - RCT Feb 2021
- Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT Dec 2020
- ICU patients greatly helped by Vitamin D loading doses – if gut-friendly – Oct 2020
- Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- 100,000 IU daily of Vitamin D for 5 days increased Hemoglobin in Mechanically Ventilated adults – RCT Jan 2018
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023
- Use of Vitamin D in a trauma surgery - Dr. Matthews on Facebook – Jan 2020
- Surgeries often deplete Vitamin D - 300,000 IU resulted in little response – Nov 2018
- 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- ICU adults getting 540,000 IU of Vitamin D were 2X more likely to be alive 30 days later – RCT June 2019
- Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT Sept 2018
- Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis April 2017
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016
- Vitamin D Loading dose - 20,000 IU daily is not enough if obese, etc. (Cancer) great table and chart – Oct 2016
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- VITdAL-ICU - AMA RCT Sept 2014
- Critically ill need vitamin D – how much and which test to use is TBD – Nov 2014
- ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014
- 540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011
- Hip surgery followed by 100000 IU then 1000 IU of vitamin D daily – June 2010
- 600,000 IU intramuscular D3 helped BMD after pancreatic surgery – June 2010
Vitamin D might help critically ill patients (if enough is given quickly) – Nov 2022Printer Friendly Follow this page for updates7618 visitors, last modified 08 Nov, 2022, This page is in the following categories (# of items in each category)